Synthesis and Evaluation of Some New Thiazoles as Antioxidant Additives for Egyptian Lubricating Oils

F. A. Amer, H. M. Hassan, E. B. Moawad, Noha Shaker


4-(2-Aminothiazol-4-yl)-phenol (1) reacted with 2-(4-methoxy-benzylidene)-malononitrile or 1,3-diphenyl-1H- pyrazole-4-carbaldehyde to afford enaminonitrile, pyrazolo derivatives 2 and 3, respectively. On the other hand, methylation of 1 afforded the acetyl derivative 4 which reacted with phenyl isothiocyanate, diazonium salt, acetic anhydride, cyclic anhydride, ethyl acetoacetate, benzaldehyde or phosphorous oxychloride to afford compounds 5-9, 11 and 12, respectively. Moreover, the compound 12 reacted with ethyl cyanoacetate to afford compound 13. A one-pot reaction of compound 1 with ethyl acetoacetate and benzaldehyde afforded compound 10. The synthesized compounds were evaluated as antioxidant additives for lube oil.
Key words: Key words: Aminothiazole; Condensation; Antioxidant Additives


Key words: Aminothiazole; Condensation; Antioxidant Additives

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